1	Course Title:	REACTIVE OXYGEN SPECIES AND ANTIOXIDANTS
2	Course Code:	VFZ6034
3	Type of Course:	Optional
4	Level of Course:	Third Cycle
5	Year of Study:	1
6	Semester:	2
7	ECTS Credits Allocated:	2
8	Theoretical (hour/week):	2
9	Practice (hour/week) :	0
10	Laboratory (hour/week) :	0
11	Prerequisites:
12	Recommended optional programme components:	None
13	Language:	Turkish
14	Mode of Delivery:	Face to face
15	Course Coordinator:	Prof. Dr. NURTEN YAKAR
16	Course Lecturers:	Prof. Dr. Nurten GALİP
17	Contactinformation of the Course Coordinator:	Prof. Dr. Nurten GALİP nurteng@uludag.edu.tr +90 224 294 1273 Uludağ Üniversitesi Veteriner Fakültesi Fizyoloji ABD Görükle Bursa 16059
18	Website:
19	Objective of the Course:	To learn the importance of antioxidants in healthy life, prevention of diseases, delaying of aging,
20	Contribution of the Course to Professional Development	To increase the knowledge and experience of students about antioxidants.

21

Learning Outcomes:

1 To be able to explain reactive oxygen species and source; 2 To be able to explain the effects of free oxygen radicals; 3 To be able to explain antioxidant defense systems against free radicals; 4 To be able to explain the positive effects created by probiotics; 5 To be able to explain the relationship between antioxidants and the aging process;

22	Course Content:

Week	Theoretical	Practical
1	to explain reactive oxygen species name, and description
2	to explain reactive oxygen species name, and description
3	Source of reactive oxygen species (ROS) in the cell
4	Effects of free oxygen radicals, (effects of radicals on lipids)
5	Effects of free radicals on proteins
6	Effects of free radicals on nucleic acids and DNA
7	Effects of free radicals on carbohydrates
8	The mechanism of action of probiotics
9	Cellular defense against free radicals (antioxidant defense systems, antioxidants
10	Cellular defense against free radicals (antioxidant defense systems, antioxidants
11	Oxidative stress and aging research
12	Oxidative stress and aging research
13	Oxidative stress and aging research
14	Oxidative stress and aging research

23	Textbooks, References and/or Other Materials:	- NOYAN, A. Yaşamda ve Hekimlikte Fizyoloji, Meteksan Ankara, 2005. GUYTON, A.C., HALL J.E.: Textbook of Medical Physiology, 11th Edition, W.B. Saunders Company, 2005. REECE, W.O: Dukes' Physiology of Domestic Animals, 12th Edition, Comstock Publishing, 2004. CUNNINGHAM JG. Textbook of Veterinary Physiology, Elsevier, USA, 2002 YILMAZ, B.: Fizyoloji, Tuğra Ajans, Ankara, 2000. Mironczuk-Chodakowska, A. M. Witkowska, and M. E.Zujko, “Endogenous non-enzymatic antioxidants in the human body,” Advances in Medical Sciences, vol. 63, no. 1, pp. 68–78, 2018. H. J. Forman, “Redox signaling: an evolution from free radicals to aging,” Free Radical Biology & Medicine, vol. 97, pp. 398–407,2016. S. Losada-Barreiro and C. Bravo-Díaz, “Free radicals and polyphenols:the redox chemistry of neurodegenerative diseases,”European Journal of Medicinal Chemistry, vol. 133, pp. 379,2017 Zerba E, Koncikowski TE, Faulkner JA. Free radical injury to skeletal muscles of young, adult, and old mice. Am J Physiol. 1990;258:C429–C35. [PubMed] Baraldi E, Dario C, Ongaro R, Scollo M, Azzolin NM, Panza N, Paganini N, Zacchello F Exhaled nitric oxide concentrations during treatment of wheezing exacerbation in infants and young children. Am J Respir Crit Care Med 1999 Apr;159(4 Pt 1):1284-8 Burtis CA, Ashwood ER. Tietz Textbook of Clinical Chemistry. W.B. Saunders Company. Philadelphia, Pennsylvania. (1999). Dawn BM, Allan DM, Colleen MS. Basic Medical Biochemistry a Clinical Approach.Lippincott Williams & Wilkins. Baltimore, Maryland.(1996).
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	1	30
Quiz	1	10
Homeworks, Performances	0	0
Final Exam	1	60
Total	3	100
Contribution of Term (Year) Learning Activities to Success Grade		40
Contribution of Final Exam to Success Grade		60
Total		100
Measurement and Evaluation Techniques Used in the Course	test exam
Information

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ECTS / WORK LOAD TABLE

Activites	NUMBER	TIME [Hour]	Total WorkLoad [Hour]
Theoretical	14	2	28
Practicals/Labs	0	0	0
Self Study and Preparation	14	2	28
Homeworks, Performances	0	0	0
Projects	0	0	0
Field Studies	0	0	0
Midtermexams	1	0	0
Others	0	0	0
Final Exams	1	4	4
Total WorkLoad			60
Total workload/ 30 hr			2
ECTS Credit of the Course			2

26	CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS
PQ1 PQ2 PQ3 PQ4 PQ5 PQ6 PQ7 PQ8 PQ9 PQ10 PQ11 PQ12 LO1 5 5 5 5 5 5 5 5 5 5 4 5 LO2 5 5 5 5 5 5 5 5 4 5 5 5 LO3 5 5 5 5 5 5 4 5 5 5 5 5 LO4 4 5 4 5 5 5 5 5 5 5 5 5 LO5 5 5 5 5 4 5 4 5 5 5 5 5

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High