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Dersin Adı: |
HETEROCYCLIC CHEMISTRY |
| 2 |
Dersin Kodu: |
KIM4048 |
| 3 |
Dersin Türü: |
Seçmeli |
| 4 |
Dersin Seviyesi: |
Lisans |
| 5 |
Dersin Verildiği Yıl: |
4 |
| 6 |
Dersin Verildiği Yarıyıl: |
8 |
| 7 |
Dersin AKTS Kredisi: |
6 |
| 8 |
Teorik Ders Saati (saat/hafta): |
3 |
| 9 |
Uygulama Ders Saati (saat/hafta): |
0 |
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Laboratuar Ders Saati (saat/hafta): |
0 |
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Dersin Önkoşulu |
None
However, it is strongly recommended that students should have read Organic Chemistry I and Organic Chemistry II.
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Ders İçin Önerilen Diğer Hususlar |
None |
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Dersin Dili: |
İngilizce |
| 14 |
Dersin Veriliş Şekli |
Yüz yüze |
| 15 |
Dersin Koordinatörü: |
Dr. Ögr. Üyesi MELİHA ÇETİN KORUKÇU |
| 16 |
Dersi Veren Diğer Öğretim Elemanları: |
Prof. Dr. Necdet COŞKUN |
| 17 |
Ders Koordinatörünün İletişim Bilgileri: |
melihacetin@uludag.edu.tr
+90 224 29 41 730
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Dersin Web Adresi: |
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Dersin Amacı |
The aim of the course is to investigate the structure, synthesis and reactivity of heterocyclic compounds. |
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Dersin Mesleki Gelişime Katkısı: |
To understand the importance and the place of heterocyclic compounds among the other organic compounds |
| Hafta |
Teori |
Uygulama |
| 1 |
Introduction to the chemistry of Heterocyclic compounds.
Nomenclature of Heterocyclic compounds.
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| 2 |
Aromatic Heterocyclic compounds: Six and five-membered six pi electron containing systems.
Benzofused heterocyclic compounds.
Other fused heterocyclic compounds.
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| 3 |
Some criteria for aromaticity in heterocyclic compounds: Bond distances, ring flow and chemical shift, thermochemical criteria for aromaticity. Tautomerism in heterocyclic compounds. |
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| 4 |
Nonaromatic heterocyclic compounds: Bond angle strain, some results of bond angle strain, angle strain and torsion energy barriers in big rings. |
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| 5 |
The effects of bond distance and van der Waals radius to conformations of saturated six, four and five membered flexible heterocycles. |
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| 6 |
Introduction of five membered ,one heteroatom containing heterocyclic compounds. Pyrroles: Ring syntheses, substitution reactions over nitrogen atom. |
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| 7 |
Substitution reactions over carbon atom at pyrrol, addition and cycloaddition reactions. Properties of substituted pyrroles, some pyrrole based natural compounds. |
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| 8 |
Furans: Ring syntheses, electrophilic substitution reactions, nucleophilic substitution reactions, cycloaddition reactions, ring opening reactions. Properties of substituted furans. |
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| 9 |
Thiophens: Ring syntheses, electrophilic substitution reactions, nucleophilic and radicalic substitution reactions, cycloaddition reactions, reductive desulphurization, photochemical isomerization. Properties of substituted thiophens. |
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| 10 |
Indoles and related compounds: Ring syntheses, acidic metallation treactions, reactions with electrophiles, oxidation and reduction. Properties of some substituted indoles. |
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| 11 |
Six membered and one heteroatom containing compounds. Pyiridines: Ring syntheses, some properties of pyridine chemistry, alkalinity, alkyllation, acylation and complexation over nitrogen. |
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Electrophilic substitutions of pyridine over carbon atoms, nucleophilic substitutions. Dehydropyridines, dihydropyridinies, pyridine-N-oxides, hydroxy and aminopyridines, pyridine carboxylic acids. |
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| 13 |
Quinolines and isoquinolines: Syntheses of quinoline and isoquinolines. Electrophilic substitutions over carbon atoms. |
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| 14 |
Nucleophilic substitutions of quinoline and isoquinoline, nucleophilic addition, oxidative ring opening, N-oxides. |
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