1	Course Title:	HETEROCYCLIC CHEMISTRY
2	Course Code:	KIM4048
3	Type of Course:	Optional
4	Level of Course:	First Cycle
5	Year of Study:	4
6	Semester:	8
7	ECTS Credits Allocated:	6
8	Theoretical (hour/week):	3
9	Practice (hour/week) :	0
10	Laboratory (hour/week) :	0
11	Prerequisites:	None However, it is strongly recommended that students should have read Organic Chemistry I and Organic Chemistry II.
12	Recommended optional programme components:	None
13	Language:	English
14	Mode of Delivery:	Face to face
15	Course Coordinator:	Dr. Ögr. Üyesi MELİHA ÇETİN KORUKÇU
16	Course Lecturers:	Prof. Dr. Necdet COŞKUN
17	Contactinformation of the Course Coordinator:	melihacetin@uludag.edu.tr +90 224 29 41 730
18	Website:
19	Objective of the Course:	The aim of the course is to investigate the structure, synthesis and reactivity of heterocyclic compounds.
20	Contribution of the Course to Professional Development	To understand the importance and the place of heterocyclic compounds among the other organic compounds

21

Learning Outcomes:

1 Understanding the importance and the place of heterocyclic compounds among the other organic compounds; 2 Learning the nomenclature of the heterocyclic compounds; 3 Learning the syntheses and properties of heterocyclic compounds;

22	Course Content:

Week	Theoretical	Practical
1	Introduction to the chemistry of Heterocyclic compounds. Nomenclature of Heterocyclic compounds.
2	Aromatic Heterocyclic compounds: Six and five-membered six pi electron containing systems. Benzofused heterocyclic compounds. Other fused heterocyclic compounds.
3	Some criteria for aromaticity in heterocyclic compounds: Bond distances, ring flow and chemical shift, thermochemical criteria for aromaticity. Tautomerism in heterocyclic compounds.
4	Nonaromatic heterocyclic compounds: Bond angle strain, some results of bond angle strain, angle strain and torsion energy barriers in big rings.
5	The effects of bond distance and van der Waals radius to conformations of saturated six, four and five membered flexible heterocycles.
6	Introduction of five membered ,one heteroatom containing heterocyclic compounds. Pyrroles: Ring syntheses, substitution reactions over nitrogen atom.
7	Substitution reactions over carbon atom at pyrrol, addition and cycloaddition reactions. Properties of substituted pyrroles, some pyrrole based natural compounds.
8	Furans: Ring syntheses, electrophilic substitution reactions, nucleophilic substitution reactions, cycloaddition reactions, ring opening reactions. Properties of substituted furans.
9	Thiophens: Ring syntheses, electrophilic substitution reactions, nucleophilic and radicalic substitution reactions, cycloaddition reactions, reductive desulphurization, photochemical isomerization. Properties of substituted thiophens.
10	Indoles and related compounds: Ring syntheses, acidic metallation treactions, reactions with electrophiles, oxidation and reduction. Properties of some substituted indoles.
11	Six membered and one heteroatom containing compounds. Pyiridines: Ring syntheses, some properties of pyridine chemistry, alkalinity, alkyllation, acylation and complexation over nitrogen.
12	Electrophilic substitutions of pyridine over carbon atoms, nucleophilic substitutions. Dehydropyridines, dihydropyridinies, pyridine-N-oxides, hydroxy and aminopyridines, pyridine carboxylic acids.
13	Quinolines and isoquinolines: Syntheses of quinoline and isoquinolines. Electrophilic substitutions over carbon atoms.
14	Nucleophilic substitutions of quinoline and isoquinoline, nucleophilic addition, oxidative ring opening, N-oxides.

23	Textbooks, References and/or Other Materials:	[1] T.L.Gilchrist, Heterocyclic Chemistry, 1985 [2] J.A.Joule aK.Mills, Heterocyclic Chemistry,Chapman and Hall, Cambridge, 2000
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	1	40
Quiz	0	0
Homeworks, Performances	0	0
Final Exam	1	60
Total	2	100
Contribution of Term (Year) Learning Activities to Success Grade		40
Contribution of Final Exam to Success Grade		60
Total		100
Measurement and Evaluation Techniques Used in the Course	Written exam
Information	None

25

ECTS / WORK LOAD TABLE

Activites	NUMBER	TIME [Hour]	Total WorkLoad [Hour]
Theoretical	14	3	42
Practicals/Labs	0	0	0
Self Study and Preparation	14	0,5	7
Homeworks, Performances	0	0	0
Projects	0	0	0
Field Studies	0	0	0
Midtermexams	1	38	38
Others	0	0	0
Final Exams	1	70	70
Total WorkLoad			157
Total workload/ 30 hr			5,23
ECTS Credit of the Course			5

26	CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS
PQ1 PQ2 PQ3 PQ4 PQ5 PQ6 PQ7 PQ8 PQ9 PQ10 PQ11 PQ12 PQ13 LO1 3 0 5 0 5 0 0 0 0 0 0 0 0 LO2 0 0 0 0 4 0 0 0 0 0 0 0 0 LO3 3 0 5 0 5 0 0 0 0 0 0 0 0

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High