esma@uludag.edu.tr (224) 2953911 U.Ü. Tıp Fakültesi, Tıbbi Biyokimya AD, Görükle- BURSA
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Website:
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Objective of the Course:
Proteins are important molecules as structural and functional elements in living organisms. It is crucial to understand protein structure, function and the realtion between them, in order to understand the basic structure and operation of the body. The aim of this course is to teach the structural and functional features of proteins in human body in an advanced level.
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Contribution of the Course to Professional Development
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Learning Outcomes:
1
To explain protein structure ;
2
To list functions of proteins;
3
To explain the mechanism of protein denaturation;
4
To explain the structure of amino acids as building blocks of proteins;
5
To explain the endogeneous amino acid synthesis pathways;
6
To explain the degradation of amino acids;
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To explain the disorders in amnio acid synthesis and degradation in a causal link;
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To list the serum proteins in order of their electrophoretic mobility;
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To relate the variations in concentration of plasma proteins with the clinical course;
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Course Content:
Week
Theoretical
Practical
1
Properties of amino acids (I)
Detection of proteins by boiling
2
Properties of amino acid (II)
Urine protein analysis
3
Amino acids in protein structure
Esbach method
4
Protein structure (I)
Brom Cresol Green method
5
Protein structure (II)
Biuret reaction
6
Protein structure (III)
Protein denaturation
7
Protein denaturation
Immunometric methods in protein analysis
8
Amino acid synthesis (I)
RID
9
Amino acid synthesis (II)
Urinary melanin
10
Degradation of amino acids and special products derived from amino acids (I)
Protein electrophoresis
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Degradation of amino acids and special products derived from amino acids (II)
Urea detection
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Degradation of amino acids and special products derived from amino acids (III)
Urinary 5-HIAA
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Plasma proteins (I)
Electrophoresis evaluation
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Plasma proteins (II)
Electrophoresis evaluation
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Textbooks, References and/or Other Materials:
1. Harper’s Biochemistry.Murray, Grammer, Mayes, Rodwell. Appleton &Lange 2. Tietz textbook of Clinical Chemistry. Ashwood. Saunders. 3. Color Atlas of Biochemistry. Koolman, Röhm. Thieme.
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Assesment
TERM LEARNING ACTIVITIES
NUMBER
PERCENT
Midterm Exam
0
0
Quiz
0
0
Homeworks, Performances
0
0
Final Exam
1
100
Total
1
100
Contribution of Term (Year) Learning Activities to Success Grade
0
Contribution of Final Exam to Success Grade
100
Total
100
Measurement and Evaluation Techniques Used in the Course
Information
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ECTS / WORK LOAD TABLE
Activites
NUMBER
TIME [Hour]
Total WorkLoad [Hour]
Theoretical
14
2
28
Practicals/Labs
14
2
28
Self Study and Preparation
14
10
140
Homeworks, Performances
0
10
50
Projects
0
0
0
Field Studies
0
0
0
Midtermexams
0
0
0
Others
0
0
0
Final Exams
1
20
20
Total WorkLoad
266
Total workload/ 30 hr
8,87
ECTS Credit of the Course
9
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CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS
