COURSE SYLLABUS

REGENERATIVE MEDICINE AND GENE THERAPY

1	Course Title:	REGENERATIVE MEDICINE AND GENE THERAPY
2	Course Code:	TIP2109
3	Type of Course:	Optional
4	Level of Course:	First Cycle
5	Year of Study:	2
6	Semester:	3
7	ECTS Credits Allocated:	3
8	Theoretical (hour/week):	1
9	Practice (hour/week) :	0
10	Laboratory (hour/week) :	0
11	Prerequisites:	None
12	Recommended optional programme components:	None
13	Language:	Turkish
14	Mode of Delivery:	Face to face
15	Course Coordinator:	Prof. Dr. ŞEHİME GÜLSÜN TEMEL
16	Course Lecturers:	Yok
17	Contactinformation of the Course Coordinator:	sehime@uludag.edu.tr 05322361646 Bursa Uludağ Üniversitesi Tıp Fakültesi Temel Tıp Bilimleri Binası Histoloji ve Embriyoloji Anabilim Dalı 16059 Nilüfer, BURSA
18	Website:	http://bilgipaketi.uludag.edu.tr/Ders/IndexENG/1116595
19	Objective of the Course:	The aim of this course is; 1. To teach the theoretical principles of regenerative medicine applications in tissues and organs in stem cell sciences and basic knowledge necessary to develop applications for new treatment approaches. 2. To provide the ability to develop new clinical treatment methods by targeted modifications of stem cells, cancer stem cells, cancer microenviroment and / or the immune system in the direction of basic research data by explaining the principles and laboratory applications to the participants. 3. To introduce the conce t of gene therapy, nonintegrative and integrative vector systems and the new Crispr / Cas9 gene editing technique to the students. Discussing the different methods used for gene targeting and follow-up, teaching the rules and regulations for the use of gene therapy in the clinic
20	Contribution of the Course to Professional Development	To teach the different methods used for gene targeting and tracking, from the laboratory to the clinic, the rules and regulations of the use of gene therapy.

Learning Outcomes:

1	At the end of this course students will 1. Know the theoretical bases of the regenerative medicine concept and discuss the cause and effects in relation of tissue and organ failure;
2	Discuss the application areas of tissue engineering and bioreactors in developing artificial tissue and organs.;
3	Know the theoretical bases of targeted treatment, understand and discuss the cause and effects in other targeted cell treatments, especially cancer cells.;
4	Understand the bases of hematopoietic and mesenchymal stem cells and gene therapy and know the different methods used in gene therapy;
5	Understand the bases of hematopoietic and mesenchymal stem cells and gene therapy and know the different methods used in gene therapy reactions associated with gene therapy and how to prevent them;
6	reactions associated with gene therapy and how to prevent them;

22	Course Content:

Week	Theoretical	Practical
1	Definition of embryonic, adult and induced plripotent stem cells
2	Embryonic and Adult stem cell types
3	Regenerative Medicine Concept
4	Regeneration with Stem Cells Targeted Therapy
5	Definition and strategies of targeted therapy
6	Definition and Strategies of Tissue Engineering
7	In vivo experimental Applications in Regenerative Medicine
8	Definition and strategies of Gene Therapy
9	Nonintegrative Vector Systems in Gene Therapy
10	Integrative Vector Systems in Gene Therapy
11	CRISPR/CAS9 Gene Editing
12	Cell and tissue specific gene targeting and follow-up methods
13	Gene Therapy and Clinical Trials
14	Legal Regulations and Ethical Rules in Regenerative Medicine Applications

23	Textbooks, References and/or Other Materials:	1. Stem Cells in Regenerative Medicine, Ed. Julie Audet and William L. Stanford, Humana Press, 2009 Toronto, Kanada. 2. Stem Cells and Human Diseases, Ed. Rakesh K. Srivastava, Sharmila Shankar, Springer Press, 2012, Heidelberg, London, New York. 3. Gene and Cell Therapy: Therapeutic Mechanisms, CRC press, 2009, editör: Templeton NS. 4. Immunology of gene therapy, Wiley-Blackwell 2008, editor: Herzog, R. ISBN13: 9780470134061. 5. A Guide To Human Gene Therapy, World Scientific Publishing Company 2010, editor: Herzog, R. ISBN13: 9789814280907. 6. Gianpietro Dotti, Barbara Savoldo, Fatma V. Okur, Raphael Rousseau, Malcolm K. Brenner (2008). Gene Therapy for the Treatment of Cancer: From Laboratory to Bedside. In Nancy Smyth Templeton (Editor), Gene and Cell Therapy: Therapeutic Mechanisms and Strategies (pp. 1001-1018). CRC Press. Stem Cells and Human Diseases, Ed. Rakesh K. Srivastara, Sharmila Shankar, Springer Press, 2012, Heidelberg, London, New York.
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	1	40
Quiz	0	0
Homeworks, Performances	0	0
Final Exam	1	60
Total	2	100
Contribution of Term (Year) Learning Activities to Success Grade		40
Contribution of Final Exam to Success Grade		60
Total		100
Measurement and Evaluation Techniques Used in the Course	There is a multiple choice midterm and a final exam.
Information	There is a midterm and a final exam.

ECTS / WORK LOAD TABLE

Activites	NUMBER	TIME [Hour]	Total WorkLoad [Hour]
Theoretical	14	1	14
Practicals/Labs	0	0	0
Self Study and Preparation	14	4	56
Homeworks, Performances	0	0	0
Projects	0	0	0
Field Studies	0	0	0
Midtermexams	1	10	10
Others	0	0	0
Final Exams	1	10	10
Total WorkLoad			100
Total workload/ 30 hr			3
ECTS Credit of the Course			3

CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS

	PQ1	PQ2	PQ3	PQ4	PQ5	PQ6	PQ7	PQ8	PQ9	PQ10	PQ11	PQ12	PQ13
LO1	5	5	0	5	0	5	4	0	5	0	0	0	0
LO2	5	0	5	0	0	5	4	0	5	0	5	0	5
LO3	5	5	0	0	5	0	3	0	5	5	5	0	0
LO4	5	0	5	0	0	5	0	5	0	5	0	5	0
LO5	5	0	5	0	5	0	0	5	0	5	0	5	0
LO6	5	0	5	0	5	0	5	0	5	0	5	0	0

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High