mtavasli@uludag.edu.tr +90 224 29 41 732 Uludağ Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, 16059 Görükle / BURSA, TÜRKİYE
18
Website:
19
Objective of the Course:
With this course, students will be able to learn how to disconnect target organic molecules and then design a viable route for the synthesis.
20
Contribution of the Course to Professional Development
To desing new molecules and to be able to sythesise them to meet commercial needs.
21
Learning Outcomes:
1
Learning and understanding the strategy of retrosynthetic approach;
2
Learning the synthetic approaches that are used for syntheses of some organic molecules having physiological effects;
3
Getting used to develop organic synthesis by their own;
4
Increasing synthetic ability in designing different molecules (e.g. pharmaceutical, paint, pesticides, polymers, perfumes, detergents, sweeteners, such as pheromones) used in the academia or industry.;
5
To reach the most current data in the literature on the working subject;
22
Course Content:
Week
Theoretical
Practical
1
Basic Approaches of Retrosynthetic Analysis
Target Molecule
Retrosynthetic Anaysis,
Functional Group Transformation
Retrosynthesis,
Idealised Anionic / Cationic Components
Reactive Compounds
2
Synthesis of Aromatic Compounds-A
Benzocaine-Local Anaesthetic
1-(4-methoxyphenyl)ethanone-Perfume Component
3
Synthesis of Aromatic Compounds-B
BHT-antioxidane
Piperonal-Perfume Component
4
Synthesis of Aromatic Compounds-C
Trifluralin- Agricultural medicine
Saccharine-Synthetic sweetening agent
5
One group C-X disconnection-A
Benzyl benzoate- Insect repeller and solvent
Propanil-Pesticide for plants in rice field
6
One group C-X disconnection-B
1-methoxy-4-methylbenzene-Perfume Component
Izopentil benzil ethere- Perfume Component
7
One group C-X disconnection-C
4-chloro-4-methylheptane
4-nitrobut-1-ene
Chemoselectivity-B
Benzyl chloroformate-Amine Protecting Group
N-Benzyloxycarbonylalanine-Protected amino acid
Captodiamine-Sedative medicine
11
Two groups C-X disconnection-A
Multistriatin- Feromone
Benzaldehyde dimethylacetal-Perfume
12
Two groups C-X disconnection-B
2-(3-chloropropyl)-2-methyl-1,3-dioxolane-Protected Ketone
Alanin-Strecker amino Acid Synthesis
13
Two groups C-X disconnection-C
Methyldopa-Hypertension medicine
2,4-D-Agricultural medicine
14
Chancing the Polarity
Alachlor- Agricultural medicine
Phenacyl chloride- Lachrymatory gase
Salbutamol-Astma medicine
23
Textbooks, References and/or Other Materials:
[1] Organic Synthesis: The Disconnection Approach, Stuart G. Warren, John Wiley & sons, New York, 1982 [2] Designing Organic Syhteses: A Programmed Introduction to the Synthon Approach, Stuart G. Warren, John Wiley & sons, New York, 1978.
24
Assesment
TERM LEARNING ACTIVITIES
NUMBER
PERCENT
Midterm Exam
1
40
Quiz
0
0
Homeworks, Performances
0
0
Final Exam
1
60
Total
2
100
Contribution of Term (Year) Learning Activities to Success Grade
40
Contribution of Final Exam to Success Grade
60
Total
100
Measurement and Evaluation Techniques Used in the Course
written exam, homework, literature search, presentation
Information
25
ECTS / WORK LOAD TABLE
Activites
NUMBER
TIME [Hour]
Total WorkLoad [Hour]
Theoretical
14
3
42
Practicals/Labs
0
0
0
Self Study and Preparation
0
0
0
Homeworks, Performances
0
3
15
Projects
0
0
0
Field Studies
0
0
0
Midtermexams
1
60
60
Others
0
0
0
Final Exams
1
64
64
Total WorkLoad
181
Total workload/ 30 hr
6,03
ECTS Credit of the Course
6
26
CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS
