COURSE SYLLABUS

BASIC RADIOBIOLOGY

1	Course Title:	BASIC RADIOBIOLOGY
2	Course Code:	TRF5009
3	Type of Course:	Compulsory
4	Level of Course:	Second Cycle
5	Year of Study:	1
6	Semester:	1
7	ECTS Credits Allocated:	2
8	Theoretical (hour/week):	1
9	Practice (hour/week) :	0
10	Laboratory (hour/week) :	0
11	Prerequisites:
12	Recommended optional programme components:	None
13	Language:	Turkish
14	Mode of Delivery:	Face to face
15	Course Coordinator:	Doç. Dr. Sibel KAHRAMAN ÇETİNTAŞ
16	Course Lecturers:	Doç.Dr. Sibel ÇETİNTAŞ Doç. Dr. Meral KURT Doc.Dr. Sürreya SARIHAN Doc.Dr. Candan Demiröz ABAKAY
17	Contactinformation of the Course Coordinator:	02242953441 skahraman@uludag.edu.tr
18	Website:
19	Objective of the Course:	Effects of ionizing radiation on living matter, mechanisms of action in this regard can teach at a cellular level description of radiobiology, the objectives, the importance of radiation to adopt to radiation oncology
20	Contribution of the Course to Professional Development

Learning Outcomes:

1	Making the definition of radiobiology;
2	Echelons of the events and to know what caused effects of ionizing radiation on living matter;
3	DNA structure, and radiation are the effects on cell proliferation and cell cycle, cell cycle phases to know the relationship between radiation sensitivity;
4	Factors affecting the biological response of normal and neoplastic tissues to prevent radiation;
5	Define the types of radiation damage to living cell formed by the general;
6	What is radiation-induced acute and late side effects and understand their reasons;
7	Understand radiobiology basis and purpose of fractionation;
8	Knowing the genetic effects of radiation caused by, to have information about cancers caused by radiation;
9	Fraksiyonasyona response factors affecting the tissues that respond to radiation, the late and early to know the relationship between the fractionation;
10	to understand the difference between Radyosensitivity and the radiocurability, to know the factors increasing and decreasing radiation response;

22	Course Content:

Week	Theoretical	Practical
1	Introduction to radiobiology
2	Physics and chemistry of radiation absorption
3	Normal Tissue and Tumor Growth Kinetics
4	Cell survival curves, radiation sensitivity, mitotic cycle
5	Radiation damage repair and the dose rate effects
6	Oxygen effect, reoxygenation
7	Dose-response relationships in normal tissues and clinical response
8	Radiation therapy doses, time and the fractionation
9	Alternative modalities of radiation, hyperthermia and photodynamic therapy
10	Radio protectors , radio sensitizers and the bio reductive agents
11	Side effects of whole body irradiation
12	LET - RBE
13	Genetic effects of radiation
14	Early and late effects in normal tissues

23	Textbooks, References and/or Other Materials:	Johns HE; “The Physics of Radiology,” Blackwell Scientific, Anonymous. International Comission on Radiation Units and Measurements. Report 62 Prescribing, Recording and Reporting Photon Beam Therapy (Supplement to ICRU Report 50), 1999. Wang CH, and Willis DL; “Radiation Methodology in Biological Sciences,” Prentice-Hall Özalpan A; “Temel Radyobiyoloji” Haliç Üniversitesi Yayınları Carlos A. Perez and Luther W. Barday ‘Principles and Practice of Radiation Oncology’
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	0	0
Quiz	0	0
Homeworks, Performances	0	0
Final Exam	1	100
Total	1	100
Contribution of Term (Year) Learning Activities to Success Grade		0
Contribution of Final Exam to Success Grade		100
Total		100
Measurement and Evaluation Techniques Used in the Course
Information

ECTS / WORK LOAD TABLE

CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High