1	Course Title:	CELL CYCLE AND APOPTOSIS
2	Course Code:	VHE 6007
3	Type of Course:	Optional
4	Level of Course:	Third Cycle
5	Year of Study:	1
6	Semester:	1
7	ECTS Credits Allocated:	5
8	Theoretical (hour/week):	1
9	Practice (hour/week) :	2
10	Laboratory (hour/week) :	0
11	Prerequisites:	None
12	Recommended optional programme components:	None
13	Language:	Turkish
14	Mode of Delivery:	Face to face
15	Course Coordinator:	Prof. Dr. BERRIN ZIK
16	Course Lecturers:	Prof. Dr. Hatice Erdost.
17	Contactinformation of the Course Coordinator:	bzik@uludag.edu.tr Uludağ Ünv. Veteriner Fak. Histoloji Embriyoloji Anabilim Dalı
18	Website:	http://www.veteriner.uludag.edu.tr
19	Objective of the Course:	Learn cell division and mechanism of physiological cell death
20	Contribution of the Course to Professional Development

21

Learning Outcomes:

1 Learn the importance of cell cycle ; 2 Learn control mechanism of cell cycle.; 3 Learn to role in tumor formation of cell cycle; 4 Learn Synchronization of cell cultures; 5 Learn cell cycle checkpoint; 6 Learning role of tumor suppressor in cell cycle ; 7 Learn the importance of apoptosis in embryology; 8 Learn the mechanism of apoptosis; 9 Learn role of apoptosis in cancer; 10 Learn the difference between apoptosis and necrosis;

22	Course Content:

Week	Theoretical	Practical
1	The cell divide: mitosis and meiosis	Examine the mitosis phases
2	Phases of cell cyle	Taking tissues and fixation
3	Growth factors and D cyclins	Paraffine blocking
4	Cell cyle restriction points and checkpoints	Taking tissue sections
5	Role of Cyclins and Cyclin-dependent kinases	Applying immunohistochemistry procedure
6	Cell cycle inhibitors	Incubation with antibody
7	Determination of cell cycle phases	Incubation with seconder antibody
8	Identification and history of apoptosis	TUNEL procedure
9	The properties of Apoptosis and Necrosis	Incubation tissues with enzyme
10	Apoptosis Inducing Factors	Examination with flourescent microscobe
11	Apoptotic mechanisms, caspases and structure of caspases	Examination with light microscobe
12	Apoptotic pathway basics: extrinsic and intrinsic pathway	Incubation with Caspases antibody
13	Inhibitors of apoptosis	Examination with flourescent and light microscobe
14	Determination of apoptosis	Troubleshooting

23	Textbooks, References and/or Other Materials:	1.Schwartz, MD Cell Death and the Caspase Cascade Circulation. 1998; 97:227-229 2.Ulukaya E Apoptosis ders notları U.Ü. Biyokimya ABD 3. Schimmer AD Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer res. 2004 Oct 15;64(20):7183-90. 4. ÖZER A.. Temel Histoloji. Nobel Yayın Sanayi Ltd Şti, Bursa, 2011.
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	0	0
Quiz	0	0
Homeworks, Performances	1	25
Final Exam	1	75
Total	2	100
Contribution of Term (Year) Learning Activities to Success Grade		25
Contribution of Final Exam to Success Grade		75
Total		100
Measurement and Evaluation Techniques Used in the Course
Information

25

ECTS / WORK LOAD TABLE

Activites	NUMBER	TIME [Hour]	Total WorkLoad [Hour]
Theoretical	14	1	14
Practicals/Labs	14	2	28
Self Study and Preparation	14	2	28
Homeworks, Performances	1	40	40
Projects	0	0	0
Field Studies	0	0	0
Midtermexams	0	0	0
Others	0	0	0
Final Exams	1	40	40
Total WorkLoad			150
Total workload/ 30 hr			5
ECTS Credit of the Course			5

26	CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS
PQ1 PQ2 PQ3 PQ4 PQ5 PQ6 PQ7 PQ8 PQ9 PQ10 PQ11 LO1 5 4 4 5 5 5 5 4 4 5 5 LO2 5 4 4 5 5 5 5 4 4 5 5 LO3 5 4 4 5 5 5 5 4 4 5 5 LO4 5 4 4 5 5 5 5 4 4 5 5 LO5 5 4 4 5 5 5 5 4 4 5 5 LO6 5 4 4 5 5 5 5 4 4 5 5 LO7 5 4 4 5 5 5 5 4 4 5 5 LO8 5 4 4 5 5 5 5 4 4 5 5 LO9 0 0 0 0 0 0 0 0 0 0 0 LO10 0 0 0 0 0 0 0 0 0 0 0

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High