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Course Title: |
ORGANIC CHEMISTRY I |
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Course Code: |
KIM2011 |
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Type of Course: |
Compulsory |
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Level of Course: |
First Cycle |
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Year of Study: |
2 |
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Semester: |
3 |
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ECTS Credits Allocated: |
4 |
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Theoretical (hour/week): |
4 |
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Practice (hour/week) : |
0 |
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Laboratory (hour/week) : |
0 |
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Prerequisites: |
Compulsory course |
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Recommended optional programme components: |
None |
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Language: |
Turkish |
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Mode of Delivery: |
Face to face |
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Course Coordinator: |
Prof. Dr. GANİ KOZA |
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Course Lecturers: |
Prof. Dr. MUSTAFA TAVASLI |
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Contactinformation of the Course Coordinator: |
ganikoza@uludag.edu.tr
+90 224 27 55 083
Bursa Uludağ Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, 16059 Görükle / BURSA, TÜRKİYE |
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Website: |
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Objective of the Course: |
To introduce organic chemistry, which is the department of chemistry. To teach the structure, properties and some basic reactions of organic molecules. |
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Contribution of the Course to Professional Development |
Gains knowledge of the properties and synthesis of organic molecules by learning Organic Chemistry. |
| Week |
Theoretical |
Practical |
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Carbon Compounds and Chemical Bonds
• Chemical Bonds: Ionic and covalent bonds
? Writing Lewis Structure
? Octet Rule and exceptions of the rule
? Formal Charge
? Resonance
• Molecular Orbital Theory
? Atomic Orbitals (s, p)
? Molecular Orbitals (?,?*, ?, ?*)
? sp3 , sp2 and sp Hybridization
? Molecular Geometry
• Presentations of Molecular Formula
? Closed,
? Structural,
? Condensed,
? Line,
? Three dimensional formulas
At the end of the course problem solving
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Functional Groups
• Polar/apolar covalent bonds
• Intermolecular forces
• Unctional Groups:
? Alkanes, Alkenes and Alkynes
? Aromatic Compounds
? Alkyl Halides
? Alcohols and Ethers
? Amines
? Aldehide and Ketons
? Carboxylic Acids, Acid chlorides, Acid anhydrides, Esters, Amides and Nitriles
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Infrared (IR) Spectroscopy:
? Electromagnetic spectrum
? Hook rule
? Molecular vibration (Stretching and Bending)
? Finger print and Functional group regions
? Absorption (A) and transmitence (T)
? Absorption frequency / wave number
? The Frequencies of Characteristic Absorptions
? Construction of the spectrum |
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Acids and Bases
• Definition of Acidity and Basicity
? Bonsted-Lowry Definition
? Lewis Definition
• Acid-Base Reactions
? The Strenghtes of Acidity and Basicity (Ka , pKa)
? Equilibrium constant and its Relationship with pKa
? Curve arrows
? The factors effecting the Acidity and Basidity
? Hybridization
? Inductive effect
? Resonance effect
? Diameter
? Positive atoms
? Solvent |
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Alkanes: Nomenclature and Conformation
• Straight and branched Alkanes:
? Nomenclature
? Structural Isomery
? Intermolecular Forces
? Conformational Analysis: Newman Projects / Sawtooth
? Ethane, propane and butane analyses
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• Cycloalkanes:
? One cyclo, two cyclo and policyclo alkanes
? Nomenclature
? cis-/trans Isomery
? Ring stretching
? Conformational Analysis: Chair / Boat
? Cyclohexane, monosubstituted cyclohexane and
di-substitutedcyclohexane analyses
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Stereochemistry
• Chiral Molecules:
? Tetrahedral carbon and chirality
? N-containing compounds and chirality
? Substituted cyclohexane and chirality
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? Determining the (R/S) Configuration
? Optical Activity
? Specific turning angle |
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• Enantiomers:
? Racemic Mixture
? Enantiomeric excess (e.e)
• Diastereoisomery:
? Diastereomeric excess (d.e.)
• Meso Compounds
• Fisher Projection Formulas
? Determining the (R/S) Configuration
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Reactions of Alkanes
• Radical Reactions:
? Homolytic Bond Breaking
? Radical Formation and Stability
? Reaction Mecanism
? Initiators, Growing and Termination
• Examples:
? Radicalic chlorination of methane
? Radicalic Addition of Hydrogen bromide to Alkanes
? Radicalic Polimerization of alkanes
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Reactions of Alkyl Halides
• Nucleophilic Substitution (SN1/SN2) Reactions:
? Nucleophile, Electrophile and Leaving Groups
? Heterolytic bond breaking
• SN2 Reaction:
? Reaction Kinetics
? Non-steady state (Walden Inversion)
? Stereochemistry
? Factors effecting the reaction rate
? The effects of Nucleophile, Electrophile, Leaving Group and Solvent
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• SN1 Reaction:
? Reaction Kinetics
? Non-steady state (Carbocation Formation)
? Stereochemistry
? Factors effecting the reaction rate
? The effects of Nucleophile, Electrophile, Leaving Group and Solvent
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• Elimination Reactions (E1/E2)
? Base, Acid and leaving group
• E2 Reaction
? Reaction Kinetics
? Non-steady state (antiperiplanar and E/Z alkene formation)
? Stereochemistry
• E1 Reaction
? Reaction Kinetics
? Non-steady state (Carbocation and steady alkene formation)
? Stereochemistry
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Alcohols
• Classification-Primer, seconder and tertier alcohols
• Physical Properties and H-Bond
• Nomenclature
• Reactions:
? Transformation to alcoxylates with base
? Transformation to alkyl halides with HX
? Transforming to alkyl bromides with PBr3
? Transformation to alkyl chlorides with POCl3, PCl5 ve SOCl2
? Transformation to alkyl tosylates,mesylates and thriphlates with TsCl, MsCl ve TfCl
? SN1/SN2 and E1/E2 reactions
? Oxidation reactions |
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