COURSE SYLLABUS

PHARMACOGENETIC

1	Course Title:	PHARMACOGENETIC
2	Course Code:	TTIP6006
3	Type of Course:	Optional
4	Level of Course:	Third Cycle
5	Year of Study:	1
6	Semester:	2
7	ECTS Credits Allocated:	5
8	Theoretical (hour/week):	2
9	Practice (hour/week) :	0
10	Laboratory (hour/week) :	0
11	Prerequisites:
12	Recommended optional programme components:	None
13	Language:	Turkish
14	Mode of Delivery:	Face to face
15	Course Coordinator:	Prof. Dr. MUSTAFA SERTAÇ YILMAZ
16	Course Lecturers:
17	Contactinformation of the Course Coordinator:	sertacyilmaz@uludag.edu.tr +90 224 295 3566 Uludağ Üniversitesi Tıp Fakültesi Tıbbi Farmakoloji Anabilim Dalı, Görükle, Bursa 16059
18	Website:
19	Objective of the Course:	This course focuses on principles of general pharmacology and pharmacogenetics which may affect the drug metabolism and action.
20	Contribution of the Course to Professional Development	Administration of the proper drug to the suitable patient via personal drug metabolism that acquired from pharmacogenetic info will decrease side effects and improve health economy.

Learning Outcomes:

1	To be able to define general information and concepts about pharmacogenetics and to describe the genetic changes in the enzymes responsible for the metabolism of drugs;;
2	To understand the mechanisms that change the effects and bioavailability of drugs at the molecular level;;
3	To be able to evaluate and differentiate genetic characteristics that change the effects of drugs used for diagnosis and treatment;;
4	To be able to define the molecules that mediate the side effects of drugs and to establish their relationship with pharmacogenetics, if any.;

22	Course Content:

Week	Theoretical	Practical
1	Introduction to Pharmacology Definition and Basic Concepts
2	Definition of Pharmacogenetics, Pharmacogenomics and Basic Concepts
3	Individual Treatments and Pharmacogenetics
4	Changes in Drug Pharmacokinetics Due to Genetic Factors - Phase I Enzymes
5	Changes in Drug Pharmacokinetics Due to Genetic Factors - Phase I Enzymes
6	Changes in Drug Pharmacokinetics Due to Genetic Factors - Phase II Enzymes
7	Changes in Drug Pharmacokinetics Due to Genetic Factors - Phase II Enzymes
8	Drug Pharmacokinetics with Case Examples
9	Pharmacogenetics of Transportor Molecules Carrying Drugs - Eflux Transporters
10	Pharmacogenetics of Transportor Molecules Carrying Drugs - Uptake Transporters
11	Pharmacogenetics of Transportor Molecules Carrying Drugs with Case Examples
12	Changes in Drug Pharmacodynamics Due to Genetic Factors - G6PDH Deficiency
13	Changes in Drug Pharmacodynamics Due to Genetic Factors - Somatic Gene Variations in Tumor Tissue
14	Pharmacogenetic Tests and Clinical Reflections

23	Textbooks, References and/or Other Materials:	- Basic and Clinical Pharmacology 15th Edition. Bertram Katzung and Anthony Trevor. The McGraw-Hill Companies, 2021.
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	0	0
Quiz	0	0
Homeworks, Performances	1	40
Final Exam	1	60
Total	2	100
Contribution of Term (Year) Learning Activities to Success Grade		40
Contribution of Final Exam to Success Grade		60
Total		100
Measurement and Evaluation Techniques Used in the Course	Measurement and evaluation are performed according to the Rules & Regulations of Bursa Uludağ University on Undergraduate Education.
Information

ECTS / WORK LOAD TABLE

CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High