COURSE SYLLABUS

REPLICATION OF VIRUSES

1	Course Title:	REPLICATION OF VIRUSES
2	Course Code:	VVR6003
3	Type of Course:	Optional
4	Level of Course:	Third Cycle
5	Year of Study:	1
6	Semester:	1
7	ECTS Credits Allocated:	4
8	Theoretical (hour/week):	2
9	Practice (hour/week) :	2
10	Laboratory (hour/week) :	0
11	Prerequisites:	None
12	Recommended optional programme components:	None
13	Language:	Turkish
14	Mode of Delivery:	Face to face
15	Course Coordinator:	Prof. Dr. KADİR YEŞİLBAĞ
16	Course Lecturers:	Prof. Dr. Kadir Yeşilbağ
17	Contactinformation of the Course Coordinator:	kyesilbag@uludag.edu.tr (+90 224) 294 12 95 U.Ü. Veteriner Fakültesi, Viroloji Anabilim Dalı, Görükle Kampüsü 16059 Bursa
18	Website:
19	Objective of the Course:	Understanding the basic replication strategies of viruses and the differences between virus families, understanding the systems that can be used in the reproduction of viruses
20	Contribution of the Course to Professional Development	Understanding the differences between the reproduction strategies of virus families and to have a command of the subject in determining the methods of struggle and the selection of diagnostic methods.

Learning Outcomes:

1	Understanding the basic replication strategies of viruses;
2	Learning the differences between virus families replication strategies;
3	Learning the systems that can be used to reproduce viruses;
4	Learning the factors that play a role in stopping the reproduction of viruses;

22	Course Content:

Week	Theoretical	Practical
1	Replication cycles of viruses	Preparation of cell culture for virus cultivation and evaluation of cell lines that can be used
2	Factors affecting adsorption and cell attachment, receptor co-receptor relationships	Application of adsorption and non-adsorption cultivation techniques in cell cultures
3	Penetration and its types	Virus production by using chemical agents that will contribute to reproduction in cell cultures
4	Methods of separating from the covering layers	Observing the effects of different adsorption times on virus replication
5	Intracellular transport of viruses and transfer of viral genome to the nucleus	Observing conditions that prevent virus growth in cell culture
6	Different synthesis stages between Eclipse stage and virus families	Observation of replicating viruses in cell culture
7	Mature virus particle formation, procapsid formation and self-assemby	Infective virus particle detection
8	Extracellular scattering strategies	Extracellular infective virus particle detection
9	Baltimore virus classification according to nucleic acid replication strategies	Detection of intracellular viral particles
10	Post-transcriptional processing	Practice of separation of DNA and RNA viruses with products that can be used in viral protein synthesis
11	Viral protein synthesis	Collection of replicated viruses
12	Post-translational processes	Standardization of antiviral agents before their use in cell culture, toxicity test
13	Antiviral agents to stop virus replication	Observation of the effects of antiviral agents on viral adsorption in cell cultures.
14	Interferon types and their effects in stopping virus replication	Observation of the effects of antiviral agents on viral replication in cell cultures

23	Textbooks, References and/or Other Materials:	Lecture notes
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	0	0
Quiz	0	0
Homeworks, Performances	0	0
Final Exam	1	100
Total	1	100
Contribution of Term (Year) Learning Activities to Success Grade		0
Contribution of Final Exam to Success Grade		100
Total		100
Measurement and Evaluation Techniques Used in the Course	The exams to be made will be made in the form of test, classical written or oral.
Information

ECTS / WORK LOAD TABLE

Activites	NUMBER	TIME [Hour]	Total WorkLoad [Hour]
Theoretical	14	2	28
Practicals/Labs	14	2	28
Self Study and Preparation	14	2	28
Homeworks, Performances	0	0	0
Projects	7	5	35
Field Studies	0	0	0
Midtermexams	0	0	0
Others	0	0	0
Final Exams	1	1	1
Total WorkLoad			120
Total workload/ 30 hr			4
ECTS Credit of the Course			4

CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS

	PQ1	PQ2	PQ3	PQ4	PQ5	PQ6	PQ7	PQ8	PQ9	PQ10	PQ11	PQ12
LO1	5	3	5	5	4	4	3	4	5	3	3	5
LO2	5	3	5	5	4	4	3	4	5	3	3	5
LO3	5	3	5	5	4	4	3	4	5	3	3	5
LO4	5	3	5	5	4	4	3	4	5	4	4	4

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High