1	Course Title:	GENETIC TOXICOLOGY
2	Course Code:	BIO6200
3	Type of Course:	Optional
4	Level of Course:	Third Cycle
5	Year of Study:	1
6	Semester:	2
7	ECTS Credits Allocated:	6
8	Theoretical (hour/week):	3
9	Practice (hour/week) :	0
10	Laboratory (hour/week) :	0
11	Prerequisites:
12	Recommended optional programme components:	None
13	Language:	Turkish
14	Mode of Delivery:	Face to face
15	Course Coordinator:	Prof. Dr. NİLÜFER ÇİNKILIÇ
16	Course Lecturers:	Prof. Dr. Tolga Çavaş
17	Contactinformation of the Course Coordinator:	aydemirn@uludag.edu.tr tcavas@uludag.edu.tr
18	Website:
19	Objective of the Course:	To provide detailed information about the methods used in the field of genetic toxicology and risk estimation analysis
20	Contribution of the Course to Professional Development	Doctorate student should understand the importance and methods of genetic toxicology well.

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Learning Outcomes:

1 llustrate physical and chemical genotoxic agents. explain efficiency mechanisms of physical chemical genotoxic agents.; 2 relate genotoxicity and DNA repair mechanisms.explain DNA repair mechanism. relate types of mutation and DNA repair.; 3 propose an genotoxicity test about an environmental agent.define genotoxicity test systems.;

22	Course Content:

Week	Theoretical	Practical
1	Introduction to Genetic toxicology-History The Application of Structure–Activity Relationships to the Prediction of the Mutagenic Activity of Chemicals
2	Bacterial Mutagenicity Assays: Test Methods
3	The Mouse Lymphoma Assay İn vivo mouse chromosome aberration tests
4	Mammalian Cell HPRT Gene Mutation Assay: Test Methods
5	The In Vitro Mammalian Chromosome Aberration Test
6	The Interpretation and Analysis of Cytogenetic Data
7	The In Vitro Micronucleus Assay
8	The In Vitro and In Vivo Comet Assays
9	Assessment of DNA Interstrand Crosslinks Using the Modified Alkaline Comet Assay
10	Cytogenetic In Vivo Assays in Somatic Cells
11	Article conversations
12	The Measurement of Induced Genetic Change in Mammalian Germ Cells
13	Article conversations
14	Transgenic Animal Mutation Models: A Review of the Models and How They Function

23	Textbooks, References and/or Other Materials:	1..Genetic Toxicology Testing 1st Edition A Laboratory Manual Editor: Ray Proudlock Paperback ISBN: 9780128007648 eBook ISBN: 9780128010068 Imprint: Academic Press Published Date: 26th May 2016 2..Principles of Genetic Toxicology Authors: Brusick, D.ISBN 978-1-4899-1980-9 3..Overview on genetic toxicology TGs. OECD 13 Apr 2017.60 pages. BOOK NUMBER 238. ISBN: 9789264274761 (PDF). https://doi.org/10.1787/9789264274761-en
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	0	0
Quiz	0	0
Homeworks, Performances	2	20
Final Exam	1	80
Total	3	100
Contribution of Term (Year) Learning Activities to Success Grade		20
Contribution of Final Exam to Success Grade		80
Total		100
Measurement and Evaluation Techniques Used in the Course	Interactions with students using projects and homeworks literature searching and translating
Information	The use of direct question and answer method during the lesson and the evaluation of the education with a written exam at the end of the year.

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ECTS / WORK LOAD TABLE

Activites	NUMBER	TIME [Hour]	Total WorkLoad [Hour]
Theoretical	14	3	42
Practicals/Labs	0	0	0
Self Study and Preparation	14	3	42
Homeworks, Performances	2	25	50
Projects	0	0	0
Field Studies	0	0	0
Midtermexams	0	0	0
Others	0	0	0
Final Exams	1	50	50
Total WorkLoad			184
Total workload/ 30 hr			6,13
ECTS Credit of the Course			6

26	CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS
PQ1 PQ2 PQ3 PQ4 PQ5 PQ6 PQ7 PQ8 PQ9 PQ10 PQ11 LO1 4 0 4 3 0 4 5 0 0 0 0 LO2 0 3 0 4 4 0 4 3 0 0 0 LO3 4 0 3 0 0 0 0 4 0 0 4

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High