1	Course Title:	MUTATIONS AND MUTAGENIC AGENTS
2	Course Code:	TTB5003
3	Type of Course:	Compulsory
4	Level of Course:	Second Cycle
5	Year of Study:	1
6	Semester:	1
7	ECTS Credits Allocated:	5
8	Theoretical (hour/week):	2
9	Practice (hour/week) :	0
10	Laboratory (hour/week) :	0
11	Prerequisites:	None
12	Recommended optional programme components:	None
13	Language:	English
14	Mode of Delivery:	Face to face
15	Course Coordinator:	Prof. Dr. Berrin Tunca
16	Course Lecturers:
17	Contactinformation of the Course Coordinator:	Prof. Dr. Gülşah ÇEÇENER gcecener@uludag.edu.tr 0224 295 41 62 ULUDAĞ ÜNİVERSİTESİ TIP FAKÜLTESİ TIBBİ BİYOLOJİ ANABİLİM DALI
18	Website:
19	Objective of the Course:	Learning basic consepts of mutations and mutagenic factors, learning types of muttaions and mechanism of their formation and linking between other subjects
20	Contribution of the Course to Professional Development	making clinical approach possible and easier

21

Learning Outcomes:

1 Understanding basic consepts of mutations and mutagenic factors.; 2 Understanding the molecular alterations in the cell and linking to related diseases.;

22	Course Content:

Week	Theoretical	Practical
1	Description of mutation
2	Concept of genome, cromosome and gene mutations
3	Description of somatic and germline mutations
4	Biogenesis of mutations
5	Hot-spot mutations
6	Non-sense mutations
7	Miss-sense mutations
8	Silent mutations
9	Frameshift mutations
10	Promoter mutations
11	Exemplify the effects of mutations to phenotipe
12	Data bases of mutations
13	Spontane and induced mutations
14	Mutagenic factors

23	Textbooks, References and/or Other Materials:	Thompson and Thompson Medical Genetic Molecular Biology of the Cell, Alberts, Garland Science Molecular Cell Biology, Lodish, WH Freeman and Company The Cell: A molecular Approach , Geoffrey M. Copper
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	0	0
Quiz	0	0
Homeworks, Performances	0	0
Final Exam	1	100
Total	1	100
Contribution of Term (Year) Learning Activities to Success Grade		0
Contribution of Final Exam to Success Grade		100
Total		100
Measurement and Evaluation Techniques Used in the Course	Semester final exam
Information	One classical exam

25

ECTS / WORK LOAD TABLE

Activites	NUMBER	TIME [Hour]	Total WorkLoad [Hour]
Theoretical	14	2	28
Practicals/Labs	0	0	0
Self Study and Preparation	12	5	60
Homeworks, Performances	0	20	20
Projects	1	30	30
Field Studies	0	0	0
Midtermexams	1	4	4
Others	0	0	0
Final Exams	1	8	8
Total WorkLoad			150
Total workload/ 30 hr			5
ECTS Credit of the Course			5

26	CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS
PQ1 PQ2 PQ3 PQ4 PQ5 PQ6 PQ7 PQ8 PQ9 PQ10 PQ11 PQ12 LO1 5 5 0 0 0 5 0 0 0 0 0 0 LO2 5 5 0 0 0 5 0 0 0 0 0 0

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High