COURSE SYLLABUS

CLINICAL LABORATORY DIAGNOSIS II

1	Course Title:	CLINICAL LABORATORY DIAGNOSIS II
2	Course Code:	VET5225
3	Type of Course:	Optional
4	Level of Course:	First Cycle
5	Year of Study:	5
6	Semester:	9
7	ECTS Credits Allocated:	3
8	Theoretical (hour/week):	1
9	Practice (hour/week) :	2
10	Laboratory (hour/week) :	0
11	Prerequisites:	None
12	Recommended optional programme components:	Recommended for small animal medicine group
13	Language:	Turkish
14	Mode of Delivery:	Face to face
15	Course Coordinator:
16	Course Lecturers:	Prof. Dr. Nazmiye Güneş Prof.Dr. Ümit Polat Prof.Dr. Bayram Şenlik Prof. Dr. Ayşin Şen Doç. Dr. Saime Güzel Doç. Dr. İ Taci Cangül Dr. Öğr. Üyesi Duygu Udum
17	Contactinformation of the Course Coordinator:	Prof. Dr. Nazmiye Güneş ngunes@uludag.edu.tr 0 224 2941282 U.Ü.Veteriner Fakültesi Biyokimya ABD
18	Website:
19	Objective of the Course:	Being able to determine and interpret biochemical parameters that aid in clinical diagnosis in in small animal medicine, and interpretation and application of physiological, pathological and microbiological
20	Contribution of the Course to Professional Development	Learning and interpreting biochemical parameters supporting clinical diagnosis in small animal medicine.

Learning Outcomes:

1	Being able to select and apply biochemical parameters that aid in clinical diagnosis in diseases resulting from pathological and metabolic disorders in small animals.;
2	Being able to apply and perform tests and methods that are used to obtain biochemical parameters and interpret results. ;
3	Being able to explain mechanisms of diseases frequently observed in small animals.;
4	Being able to choose clinical material that are used in diagnosis of small animal diseases and apply biopsy techniques. ;
5	Being able to utilize diagnostic methods in immune disorders and parasitic infestations frequently observed in small animals. ;
6	Being able to integrate all diagnostic knowlede acquired about small animal diseases and use in diagnosis of diseases;
7	Being able to communicate with workers and animal owners;
8	Being able to disseminate knowledge gained about clinical biochemical methods in diagnosis of small animal diseases verbally and in writing.;

22	Course Content:

Week	Theoretical	Practical
1	Coagulation and diagnosis of clotting disorders.	Determination of the clotting time with Lee-White method; Prothrombin time (PT)-Quicks one -stage method
2	Clinical enzymology and interpretation	Measurement of serum AST and ALT
3	Laboratory tests in liver diseases: albumin, globulin, ammonia and urea nitrogen, starvation blood ammonia tolerance test, hypo and hyperproteinemia, diagnostic approach to hyperglobulinemia	Analysis of serum total protein and gluteraldehyde test
4	Tests of hepatic metabolism: bilirubin metabolism and icterus, diagnostic approach to urine bilirubin, urobilinogen and high serum bile acids	Ehrlich’s benzaldehyde test, determination of urobilinogen and bile acids in urine, the determination of bilirubin by using Fauchet’s test, the use of urine strips
5	Test of gastric acid secretion, exocrine pancreatic tests, interpretation of hyperamilasemia and hyperlipasemia	A case oriented discussion related to pancreatic diseases (acute-chronic pancreatitis)
6	Glomerular function tests: interpretation of azotemia, creatinine clearance, tubuler function tests, other serum biochemical findings in renal diseases	The microscopic examination of urine sediment, interpretation of crystals found in acid and alkaline urine
7	Plasma calcium fractions, hypo and hypercalcemia, interpretation of hypo and hyperphosphatemia, primary hypoparathyroidism, primary and secondary hyperparathyroidism, the expression and tests of biochemical mechanism of Addison’s disease and Cushing’s syndrome	Analysis of serum calcium and inorganic phosphorus and a case oriented discussion related to Addison’s disease and Cushing’s syndrome
8	Interpretation of diagnostic test results in hypo- and hyperthyroidism	A case oriented discussion related to hypo- and hyperthyroidism
9	Pancreatic endocrine function, the tests used in diagnosis of diabetes mellitus and insipidus, interpretation of hypoglycemia and hyperglycemia, the tolerance tests of glucose and galactose	Measurement of urine density and determination of blood glucose level
10	Lipoproteins, interpretation of hyperlipidemia and hypo- and hypercholesterolemia	Analysis of serum total lipid and cholesterol
11	Immunologic mechanisms in immune mediated diseases, immunologic mechanisms of canine and feline IgE and immune complex mediated disease	Erythrocyte agglutination tests, anti-erythrocyte antibody tests, anti-nuclear antibody tests, anti-thrombocyte antibody tests, rheumatoid factor test
12	Sampling from lymph node aspirates, bone marrow, nasal discharge, etc. Sampling and evaluating transudates and exudates	Preparing cytological smears from lymph nodes, organs, transudates and exudates obtained from slaughterhouses and clinics; discussion of archive cases
13	Skin biopsies: sampling and evaluation	Sampling skin biopsies; discussion of archive cases
14	Laboratory diagnostic techniques and interpretation of the results in parasitic diseases	Quantitative examination techniques, their values, evaluations and applicabilities in parasitology

23	Textbooks, References and/or Other Materials:	Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics , Carl A Burtis, David E.Bruns , Elsevier,2014. Genel ve Klinik Biyokimya, M. Üstdal, O. Donma, R. Vuillaume, K. Dolbun,1. Baskı Güneş Tıp Kitabevleri, 2017. Klinik Laboratuvar Tanı, Turgut K. II. Baskı, İstanbul, 2002 Guyton Tıbbi Fizyoloji, Hall J.E.,Güneş Tıp Kitabevleri , 13. Baskı, 2017 Şen A; Veteriner İmmunoloji, İkinci Baskı, Dora Yayıncılık, Bursa, 2019 Textbook of clinical parasitology in dogs and cats. .Beugnet, F., Halos, L., Guillot, J. ss. 432. Servet editorial Grupo Asís Biomedia, S.L.. Spain. (2018). Freeman KP, Klenner S. Veterinary Clinical Pathology: A Case-Based Approach. CRC Press, Londra, İngiltere, 2015
24	Assesment

TERM LEARNING ACTIVITIES	NUMBER	PERCENT
Midterm Exam	1	40
Quiz	0	0
Homeworks, Performances	0	0
Final Exam	1	60
Total	2	100
Contribution of Term (Year) Learning Activities to Success Grade		40
Contribution of Final Exam to Success Grade		60
Total		100
Measurement and Evaluation Techniques Used in the Course	The exams will be made in the form of test or classical written
Information

ECTS / WORK LOAD TABLE

Activites	NUMBER	TIME [Hour]	Total WorkLoad [Hour]
Theoretical	14	1	14
Practicals/Labs	14	2	28
Self Study and Preparation	5	3	15
Homeworks, Performances	0	0	0
Projects	0	0	0
Field Studies	0	0	0
Midtermexams	1	10	10
Others	1	8	8
Final Exams	1	15	15
Total WorkLoad			90
Total workload/ 30 hr			3
ECTS Credit of the Course			3

CONTRIBUTION OF LEARNING OUTCOMES TO PROGRAMME QUALIFICATIONS

	PQ1	PQ2	PQ3	PQ4	PQ5	PQ6	PQ7	PQ8	PQ9	PQ10	PQ11	PQ12
LO1	4	1	5	5	1	1	1	3	1	1	1	1
LO2	4	1	5	4	1	1	1	1	1	1	1	1
LO3	4	5	5	1	4	1	1	0	0	1	1	1
LO4	4	0	4	3	1	1	1	1	1	1	0	1
LO5	4	0	3	3	1	1	1	1	1	1	1	1
LO6	5	2	5	1	1	1	1	0	1	1	0	0
LO7	1	4	1	1	1	1	1	1	5	1	1	1
LO8	1	1	1	1	1	1	1	1	5	5	1	1

LO: Learning Objectives

PQ: Program Qualifications

Contribution Level:

1 Very Low

2 Low

3 Medium

4 High

5 Very High